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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MEF2D
All Species:
19.39
Human Site:
T274
Identified Species:
35.56
UniProt:
Q14814
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q14814
NP_005911.1
521
55938
T274
K
P
D
L
R
V
I
T
S
Q
A
G
K
G
L
Chimpanzee
Pan troglodytes
XP_001165500
521
55889
T274
K
P
D
L
R
V
I
T
S
Q
A
G
K
G
L
Rhesus Macaque
Macaca mulatta
XP_001103222
500
53974
I272
K
P
D
L
R
V
V
I
P
P
S
S
K
G
M
Dog
Lupus familis
XP_547534
525
56508
R274
G
N
G
Y
V
S
A
R
A
S
P
G
L
L
P
Cat
Felis silvestris
Mouse
Mus musculus
Q63943
514
54974
T274
K
P
D
L
R
V
I
T
S
Q
G
G
K
G
L
Rat
Rattus norvegicus
O89038
507
54350
T274
K
P
D
L
R
V
I
T
S
Q
G
G
K
G
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507540
505
54598
V274
R
K
P
D
L
R
V
V
I
P
P
S
S
K
G
Chicken
Gallus gallus
Q9W6U8
499
53650
I276
K
P
D
L
R
V
V
I
P
P
S
S
K
G
M
Frog
Xenopus laevis
Q03413
498
54053
T274
K
P
D
L
R
V
I
T
S
Q
G
G
K
G
L
Zebra Danio
Brachydanio rerio
NP_571392
529
57466
S274
R
V
I
T
S
Q
S
S
K
G
L
M
Q
L
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P40791
539
57097
Q274
V
G
Y
A
D
Q
R
Q
S
Q
T
S
L
N
T
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q38847
268
30310
E56
S
K
S
G
K
L
F
E
Y
S
S
T
G
M
K
Baker's Yeast
Sacchar. cerevisiae
Q12224
676
73465
S274
K
P
F
T
N
A
S
S
R
T
P
K
Q
E
H
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.8
53.7
72.5
N.A.
96.1
94.4
N.A.
54.1
54.7
73.6
70.1
N.A.
28
N.A.
N.A.
N.A.
Protein Similarity:
100
99.8
63.9
75.8
N.A.
97.1
95.5
N.A.
64.8
64.3
82.5
78.2
N.A.
39.5
N.A.
N.A.
N.A.
P-Site Identity:
100
100
53.3
6.6
N.A.
93.3
93.3
N.A.
0
53.3
93.3
0
N.A.
13.3
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
73.3
13.3
N.A.
93.3
93.3
N.A.
13.3
73.3
93.3
20
N.A.
13.3
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
22.2
22.1
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
34.9
38.4
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
8
0
8
8
0
8
0
16
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
54
8
8
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
8
0
0
0
0
0
8
0
% E
% Phe:
0
0
8
0
0
0
8
0
0
0
0
0
0
0
0
% F
% Gly:
8
8
8
8
0
0
0
0
0
8
24
47
8
54
8
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% H
% Ile:
0
0
8
0
0
0
39
16
8
0
0
0
0
0
0
% I
% Lys:
62
16
0
0
8
0
0
0
8
0
0
8
54
8
8
% K
% Leu:
0
0
0
54
8
8
0
0
0
0
8
0
16
16
39
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
8
0
8
16
% M
% Asn:
0
8
0
0
8
0
0
0
0
0
0
0
0
8
0
% N
% Pro:
0
62
8
0
0
0
0
0
16
24
24
0
0
0
8
% P
% Gln:
0
0
0
0
0
16
0
8
0
47
0
0
16
0
0
% Q
% Arg:
16
0
0
0
54
8
8
8
8
0
0
0
0
0
0
% R
% Ser:
8
0
8
0
8
8
16
16
47
16
24
31
8
0
0
% S
% Thr:
0
0
0
16
0
0
0
39
0
8
8
8
0
0
16
% T
% Val:
8
8
0
0
8
54
24
8
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
8
8
0
0
0
0
8
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _